Article
DNA sequencing of viral capsid protein VP-1 region in patients with BK virus interstitial nephritis.
Transplantation - 15 Apr 2002
Randhawa Parmjeet S, Khaleel-Ur-Rehman K, Swalsky Patricia A, Vats Abhay, Scantlebury Velma, Shapiro Ron, Finkelstein Sydney
Abstract excerpt
BACKGROUND: Mutations in the viral capsid protein VP-1 region are associated with increased pathogenicity of polyomavirus in experimental systems. This study sought to determine whether analogous viral genetic changes occur in human BK virus (BKV) interstitial nephritis (ISN). METHODS: PCR was used to amplify a 94-bp nucleotide sequence of the viral capsid protein VP-1 region (positions 1740-1833, Dun numbering)...
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