Article
Molecular characterization of human polyomavirus JC in Brazilian AIDS patients with and without progressive multifocal leukoencephalopathy.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2010
Fink Maria Cristina Domingues, de Oliveira Augusto Cesar Penalva, Romano Camila Malta, Vidal Jose Ernesto, Urbano Paulo Roberto Palma, Tateno Adriana Fumie, Oliveira Cristina Mendes, de Albuquerque Luna Expedito José, Pannuti Claudio Sérgio
Abstract excerpt
BACKGROUND: JC virus (JCV), the causative agent of progressive multifocal leukoencephalopathy (PML), is classified in 8 different genotypes. Previous reports have suggested a positive association between specific genotypes and PML. OBJECTIVE: To compare genotypes and adaptive mutations of JCV strains from Brazilian AIDS patients with and without PML. STUDY DESIGN: The VP1 region of JCV was amplified by polymerase...
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