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Article

Global genome repair is required to activate KIN17 , a UVC-responsive gene involved in DNA replication

13 Jan 2003

Abstract excerpt

UV light provokes DNA lesions that interfere with replication and transcription. These lesions may compromise cell viability and usually are removed by nucleotide excision repair (NER). In humans, inactivation of NER is associated with three rare autosomal recessive inherited disorders: xeroderma pigmentosum (XP), Cockayne syndrome, and trichothiodystrophy. The NER earliest step is lesion recognition by a complex...

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PMID: 12525703
DOI: 10.1073/pnas.0236176100

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