Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The foot-and-mouth disease virus cis-acting replication element (cre) can be complemented in trans within infected cells.

Journal of virology - 1 Feb 2003

Tiley Laurence, King Andrew M Q, Belsham Graham J

Abstract excerpt

A temperature-sensitive (ts) mutation was identified within the 5'-untranslated region of foot-and-mouth disease virus (FMDV) RNA. The mutation destabilizes a stem-loop structure recently identified as a cis-acting replication element (cre). Genetic analyses indicated that the ts defect in virus replication could be complemented. Thus, the FMDV cre can function in trans. It is suggested that the cre be renamed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Cricetinae
Share to Foot-and-Mouth Disease Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Nucleic Acid Conformation

Share to Regulatory Sequences, Nucleic Acid

Share to RNA, Viral

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 12525659
DOI: 10.1128/jvi.77.3.2243-2246.2003
PMCID: PMC140903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The foot-and-mouth disease virus cis-acting replication element (cre) can be complemented in trans within infected cells.PMID 12525659Read ↗

Identification and Characterization of a <i>cis</i> -Acting Replication Element ( <i>cre</i> ) Adjacent to the Internal Ribosome Entry Site of Foot-and-Mouth Disease VirusSemantic proximity Read ↗

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication but essential for the production of infectious virusSemantic proximity Read ↗

Structure and function analysis of the poliovirus <i>cis</i>-acting replication element (CRE)Semantic proximity Read ↗

Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localised in the Polymerase (3D <sup>pol</sup> ) Encoding RegionSemantic proximity Read ↗

The majority of the nucleotides in the top loop of the genomic 3' terminal stem loop structure are cis-acting in a West Nile virus infectious clone.Semantic proximity Read ↗

Insights into polyprotein processing and RNA-protein interactions in foot-and-mouth disease virus genome replicationSemantic proximity Read ↗

Genetic and biochemical studies of poliovirus cis-acting replication element cre in relation to VPg uridylylation.Semantic proximity Read ↗

A Temperature-Dependent Translation Defect Caused by Internal Ribosome Entry Site Mutation Attenuates Foot-and-Mouth Disease Virus: Implications for Rational Vaccine Design.Semantic proximity Read ↗

Both <i>cis</i> and <i>trans</i> Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA ReplicationSemantic proximity Read ↗

The 3′ <i>cis</i> -Acting Genomic Replication Element of the Severe Acute Respiratory Syndrome Coronavirus Can Function in the Murine Coronavirus GenomeSemantic proximity Read ↗

Large deletions in the 5′-untranslated region of foot-and-mouth disease virus of serotype CSemantic proximity Read ↗

Differential RNA Sequence Requirement for Dengue Virus Replication in Mosquito and Mammalian CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.