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Article

Structure and function analysis of the poliovirus <i>cis</i>-acting replication element (CRE)

1 Jan 2003

Abstract excerpt

The poliovirus cis-acting replication element (CRE) templates the uridylylation of VPg, the protein primer for genome replication. The CRE is a highly conserved structural RNA element in the enteroviruses and located within the polyprotein-coding region of the genome. We have determined the native structure of the CRE, defined the regions of the structure critical for activity, and investigated the influence of...

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PMID: 12554882
DOI: 10.1261/rna.2950603

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