Identification and Characterization of a <i>cis</i> -Acting Replication Element ( <i>cre</i> ) Adjacent to the Internal Ribosome Entry Site of Foot-and-Mouth Disease Virus

Abstract excerpt

Over the last few years, an essential RNA structure known as the cis-acting replicative element (cre) has been identified within the protein-coding region of several picornaviruses. The cre, a stem-loop structure containing a conserved AAACA motif, functions as a template for addition of U residues to the protein primer 3B. By surveying the genomes of representatives of several serotypes of foot-and-mouth disease...

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