Article
Functional analysis of nsP3 phosphoprotein mutants of Sindbis virus.
Journal of virology - 1 Dec 2003
Dé Indra, Fata-Hartley Cori, Sawicki Stanley G, Sawicki Dorothea L
Abstract excerpt
Alphavirus nsP3 phosphoprotein is essential for virus replication and functions initially within polyprotein P123 or P23 components of the short-lived minus-strand replicase, and upon polyprotein cleavage, mature nsP3 likely functions also in plus-strand synthesis. We report the identification of a second nsP3 mutant from among the A complementation group of Sindbis virus (SIN) heat-resistant strain, ts...
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