Article
Multiple drug-resistant Mycobacterium tuberculosis: evidence for changing fitness following passage through human hosts.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2002
Gillespie Stephen H, Billington Owen J, Breathnach Aodhan, McHugh Timothy D
Abstract excerpt
Recent studies have shown a difference in the genotype of resistant bacteria following passage in animals compared to those passaged in vitro. This suggests that organisms rapidly adapt to their environment of growth. We sought to investigate whether this phenomenon occurred in human infection and whether changes could be detected in the fitness (growth velocity) of isolates transmitted between human hosts....
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