Article
[Individualized pharmacotherapy based on cytochrome P-450 (CYP) genotyping].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke - 30 Nov 2002
Johansen Per Wiik, Bergan Stein, Rootwelt Helge, Kvittingen Eli Anne, Rugstad Hans Erik
Abstract excerpt
BACKGROUND: Genetic polymorphisms of the drug-metabolising cytochrome P-450 (CYP) enzymes CYP2C9, CYP2C19 and CYP2D6 have been characterized, and several of these variants lead to reduced or absent activity. This is of clinical importance mainly in patients having two non-functional alleles, phenotypically characterised as "poor metabolisers" (1-10% of Caucasians). Since most drugs are transformed into inactive...
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