Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.

Human genetics - 1 Feb 2003

Andreassi Maria Grazia, Botto Nicoletta, Cocci Franca, Battaglia Debora, Antonioli Elisabetta, Masetti Serena, Manfredi Samantha, Colombo Maria Giovanna, Biagini Andrea, Clerico Aldo

Abstract excerpt

Elevated levels of plasma homocysteine (Hcy), a risk factor for coronary artery disease (CAD), can result from genetic errors, e.g., the methylenetetrahydrofolate reductase (MTHFR) polymorphism, or nutritional deficiencies, e.g., in vitamin B12 and folate. The mechanism by which Hcy induces atherosclerosis is not fully understood. Recently, Hcy has also been observed to induce DNA damage. In this study, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carotid Artery Diseases
Share to Coronary Angiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine

Share to Homocysteine

Share to Micronucleus Tests

Share to Oxidoreductases Acting on CH-NH Group Donors

Share to Thymidine

Share to Vitamin B 12

Source

Identifiers

PMID: 12522558
DOI: 10.1007/s00439-002-0859-3

Genes

CAD
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease.PMID 12522558Read ↗

High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.Semantic proximity Read ↗

Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery diseaseSemantic proximity Read ↗

Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD.Semantic proximity Read ↗

Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.Semantic proximity Read ↗

Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other populations.Semantic proximity Read ↗

Myocardial Infarction in Young Women in Relation to Plasma Total Homocysteine, Folate, and a Common Variant in the Methylenetetrahydrofolate Reductase GeneSemantic proximity Read ↗

Methylenetetrahydrofolate reductase gene and coronary artery disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.