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Article

Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α

5 Oct 2015

Abstract excerpt

In recent years an extensive effort has been made to elucidate the molecular pathways involved in metabolic signaling in health and disease. Here we show, surprisingly, that metabolic regulation and the heat-shock/stress response are directly linked. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a critical transcriptional coactivator of metabolic genes, acts as a direct transcriptional...

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PMID: 26438876
DOI: 10.1073/pnas.1516219112

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