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Article

Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.

The Journal of biological chemistry - 26 May 2000

Tcherepanova I, Puigserver P, Norris J D, Spiegelman B M, McDonnell D P

Abstract excerpt

A transcriptional coactivator of the peroxisome proliferator-activated receptor-gamma (PPARgamma), PPARgamma-coactivator-1(PGC-1) interacts in a constitutive manner with the hinge domain of PPARgamma and enhances its transcriptional activity. In this study we demonstrate that PGC-1 is a coactivator of estrogen receptor-alpha (ERalpha)-dependent transcriptional activity. However the mechanism by which PGC-1...

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Share to Estrogen Receptor alpha
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10748020
DOI: 10.1074/jbc.M001364200

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.PMID 10748020Read ↗

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