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Article

Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis.

Biochemistry - 21 May 2002

Zhang Bin, Peng Zheng-yu

Abstract excerpt

The cyclin-dependent kinase inhibitor p16(INK4a) (hereafter p16) functions as a multiple tumor suppressor. Mutations in p16, which are distributed throughout the entire protein, have been identified in a variety of human cancers and cancer-derived cell lines. It is unclear how tumor-derived mutations disrupt the structure and function of p16, especially since many of these mutations are located far away from the...

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PMID: 12009890
DOI: 10.1021/bi0117100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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