Article
Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2003
Christov K T, Shilkaitis A L, Kim E S, Steele V E, Lubet R A
Abstract excerpt
Terminal replicative senescence (TRS) is a physiological process associated with terminal differentiation, shortening of the telomere, and lack of proliferative activity. Immortalised and tumour cells have lost their differentiation potential and the ability to develop a senescence phenotype. Recently, others and we [11] have observed that some antitumour agents and radiation induce a senescence-like phenotype...
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