Article
High rate of occult cancer found in prophylactic mastectomy specimens despite thorough presurgical assessment with MRI and ultrasound: findings from the Hereditary Breast and Ovarian Cancer Registration 2016 in Japan.
Breast cancer research and treatment - 1 Dec 2018
Yamauchi Hideko, Okawa Megumi, Yokoyama Shiro, Nakagawa Chizuko, Yoshida Reiko, Suzuki Koyu, Nakamura Seigo, Arai Masami
Abstract excerpt
PURPOSE: Prophylactic surgery is a preemptive strategy for hereditary breast and ovarian cancer (HBOC). Prophylactic mastectomy (PM) reduces breast cancer risk by > 90%. The aim of our study is to analyze the information of the Japanese pedigrees and to utilize the results for clinical practice. METHODS: We statistically analyzed records of HBOC registrees who had undergone BRCA1/2 genetic testing at seven...
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