Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

JunB gene expression is inactivated by methylation in chronic myeloid leukemia

2 Apr 2003

Abstract excerpt

JunB is a component of the Jun family genes of the activating protein-1 transcription factors that are important in the control of cell growth and differentiation and neoplastic transformation. Recently, it was demonstrated that transgenic mice specifically lacking JunB expression in the myeloid lineage developed a myeloproliferative disease, eventually progressing to blast crisis that resembled human chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Chronic Myeloid Leukemia Treatments
Share to Kruppel-like factors research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12506033
DOI: 10.1182/blood-2002-05-1598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

JunB gene expression is inactivated by methylation in chronic myeloid leukemiaPMID 12506033Read ↗

Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage.Semantic proximity Read ↗

c-JUN promotes BCR-ABL–induced lymphoid leukemia by inhibiting methylation of the 5′ region of Cdk6Semantic proximity Read ↗

ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia.Semantic proximity Read ↗

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineageSemantic proximity Read ↗

JunB inhibits proliferation and transformation in B-lymphoid cellsSemantic proximity Read ↗

Proto-Oncogenes of the <i><i>fos/jun</i></i> Family of Transcription Factors are Positive Regulators of Myeloid DifferentiationSemantic proximity Read ↗

Promoter-specific trans-activation and inhibition mediated by JunB.Semantic proximity Read ↗

JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemiaSemantic proximity Read ↗

The role of aberrant transcription factor in the progression of chronic myeloid leukemia.Semantic proximity Read ↗

Defective endochondral ossification in mice with strongly compromised expression of JunB.Semantic proximity Read ↗

Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors.Semantic proximity Read ↗

Both Jun and Fos contribute to transcription activation by the heterodimer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.