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Article

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage

9 Oct 2008

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18843287
DOI: 10.1038/leu.2008.275

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Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineagePMID 18843287Read ↗

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ATM mediates constitutive NF-κB activation in high-risk myelodysplastic syndrome and acute myeloid leukemiaSemantic proximity Read ↗

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activationSemantic proximity Read ↗

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cellsSemantic proximity Read ↗

JunB gene expression is inactivated by methylation in chronic myeloid leukemiaSemantic proximity Read ↗

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.Semantic proximity Read ↗

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenesSemantic proximity Read ↗

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