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Article

Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors.

The Journal of biological chemistry - 24 Oct 2008

Mori Masaaki, Yoneda-Kato Noriko, Yoshida Akihiro, Kato Jun-ya

Abstract excerpt

Overexpression of JAB1 is observed in a variety of human cancers, but how JAB1 is involved in tumor development remained to be investigated. Here we analyzed mice with modified Jab1 expression. Mice ectopically expressing a more stable form of JAB1 protein under the control of a constitutive promoter were rescued from the embryonic lethality caused by the Jab1(-/-) allele and developed a myeloproliferative...

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Source

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Identifiers

PMID: 18667426
DOI: 10.1074/jbc.M804539200
PMCID: PMC2662005

Genes

SMYD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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