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Article

Lack of susceptibility of heterozygous p53-knockout CBA and CIEA mice to phenolphthalein in a 6-month carcinogenicity study.

Toxicology - 14 Mar 2003

Okamura Miwa, Kashida Yoko, Watanabe Takao, Yasuhara Kazuo, Onodera Hiroshi, Hirose Masao, Usui Toshimi, Tamaoki Norikazu, Mitsumori Kunitoshi

Abstract excerpt

Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in female heterozygous p53-knockout TSG mice (C57BL/6 background) at the same dose in a 6-month study. To examine whether carcinogenic potential of phenolphthalein can be detected in other p53-knockout mouse [p53 (+/-)] strains such as p53 (+/-) CBA mice or p53...

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Source

Identifiers

PMID: 12505441
DOI: 10.1016/s0300-483x(02)00586-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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