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Article

Loss of cryptochrome reduces cancer risk in p53 mutant mice.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2009

Ozturk Nuri, Lee Jin Hyup, Gaddameedhi Shobhan, Sancar Aziz

Abstract excerpt

It is commonly thought that disruption of the circadian clock increases the cancer incidence in humans and mice. However, it was found that disruption of the clock by the Cryptochrome (Cry) mutation in mice did not increase cancer rate in the mutant mice even after exposing the animals to ionizing radiation. Therefore, in this study we tested the effect of the Cry mutation on carcinogenesis in a mouse strain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19188586
DOI: 10.1073/pnas.0813028106
PMCID: PMC2634797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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