Article
Function of CD4 molecules in LEC rat thymocytes.
The Journal of veterinary medical science - 1 Nov 1996
Sakai T, Agui T, Muramatsu Y, Yamada T, Hisaeda H, Himeno K, Matsumoto K
Abstract excerpt
Long-Evans Cinnamon (LEC) rats show a novel maturational arrest from CD4+8+ to CD4+8- thymocytes but a cause of this mutation is not identified. The candidate for this mutation is a defect in the function of CD4 or major histocompatibility complex (MHC) class II because gene-disrupted mice defective for CD4 or MHC class II molecules show a specific defect in CD4+ T cells. Previously, we showed that MHC class II...
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