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Shiga Toxins 1 and 2 Translocate Differently across Polarized Intestinal Epithelial Cells

1 Dec 1999

Abstract excerpt

Shiga toxin-producing Escherichia coli (STEC) is an important food-borne pathogen that causes hemolytic-uremic syndrome. Following ingestion, STEC cells colonize the intestine and produce Shiga toxins (Stx), which appear to translocate across the intestinal epithelium and subsequently reach sensitive endothelial cell beds. STEC cells produce one or both of two major toxins, Stx1 and Stx2. Stx2-producing STEC is...

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Identifiers

PMID: 10569789
DOI: 10.1128/iai.67.12.6670-6677.1999

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