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Article

A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study.

Lancet (London, England) - 30 Mar 2002

Wiley James S, Dao-Ung L Phuong, Gu Ben J, Sluyter Ronald, Shemon Anne N, Li Changping, Taper John, Gallo John, Manoharan Arumugam

Abstract excerpt

BACKGROUND: Chronic lymphocytic leukaemia (CLL) has a familial incidence nearly three times higher than expected for the general population and one predisposing factor might be an inherited failure of mechanisms involved in apoptosis of lymphocytes. Our aim was to ascertain whether or not a defect in a proapoptotic pathway, caused by a single nucleotide polymorphism that results in loss-of-function of P2X7 in...

Read the complete abstract on PubMed

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Share to Apoptosis
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Point Mutation

Share to Receptors, Purinergic P2

Share to Receptors, Purinergic P2X7

Source

Identifiers

PMID: 11943260
DOI: 10.1016/S0140-6736(02)08156-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study.PMID 11943260Read ↗

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