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Article

1513A/C polymorphism in the P2X7 receptor gene in chronic lymphocytic leukemia: absence of correlation with clinical outcome.

European journal of haematology - 1 Apr 2004

Nückel Holger, Frey Ulrich H, Dürig Jan, Dührsen Ulrich, Siffert Winfried

Abstract excerpt

Purinergic P2X7 receptors are ligand-gated cation channels expressed on the cells of the immune and hemopoietic system which have been shown to mediate the ATP-induced apoptotic death of monocytes, macrophages and lymphocytes. A common single nucleotide polymorphism within the P2X7 gene has been described in exon 13 (1513A/C), the gene products encoding fully active and non-functional proteins. We genotyped the...

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Identifiers

PMID: 15089763
DOI: 10.1111/j.0902-4441.2003.00210.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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1513A/C polymorphism in the P2X7 receptor gene in chronic lymphocytic leukemia: absence of correlation with clinical outcome.PMID 15089763Read ↗

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P2X7 polymorphism and chronic lymphocytic leukaemia: lack of correlation with incidence, survival and abnormalities of chromosome 12.Semantic proximity Read ↗

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A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.Semantic proximity Read ↗

Association between the rs3751143 polymorphism of P2RX7 gene and chronic lymphocytic leukemia: A meta-analysis.Semantic proximity Read ↗

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