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Article

PAR-1 is required for morphogenesis of the Caenorhabditis elegans vulva.

Developmental biology - 1 Jan 2003

Hurd Daryl D, Kemphues Kenneth J

Abstract excerpt

The Caenorhabditis elegans vulva provides a simple model for the genetic analysis of pattern formation and organ morphogenesis during metazoan development. We have discovered an essential role for the polarity protein PAR-1 in the development of the vulva. Postembryonic RNA interference of PAR-1 causes a protruding vulva phenotype. We found that depleting PAR-1 during the development of the vulva has no...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Female
Immunohistochemistry
Morphogenesis
Phenotype
Protein Serine-Threonine Kinases
Vulva

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12490197
DOI: 10.1006/dbio.2002.0866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12490197-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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PAR-1 is required for morphogenesis of the Caenorhabditis elegans vulva.PMID 12490197Read ↗

Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline.Semantic proximity Read ↗

PAR-3 mediates the initial clustering and apical localization of junction and polarity proteins during C. elegans intestinal epithelial cell polarization.Semantic proximity Read ↗

Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumenSemantic proximity Read ↗

A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.Semantic proximity Read ↗

RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.Semantic proximity Read ↗

Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling.Semantic proximity Read ↗

MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.Semantic proximity Read ↗

lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development.Semantic proximity Read ↗

The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells.Semantic proximity Read ↗

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