Article
Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling.
Developmental biology - 15 Mar 2010
Hoffmann Michael, Segbert Christoph, Helbig Gisela, Bossinger Olaf
Abstract excerpt
Understanding how epithelial organs form during morphogenesis is a major problem in developmental biology. In the present paper, we provide a detailed analysis of vang-1, the only homolog of the planar cell polarity protein Strabismus/Van Gogh in Caenorhabditis elegans. We demonstrate that during organogenesis of the intestine, (i) VANG-1 specifically interacts with PDZ 2 domain of DLG-1 (Discs large) and becomes...
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