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Article

Internalization and sequestration of the human prostacyclin receptor.

The Journal of biological chemistry - 13 Oct 2000

Smyth E M, Austin S C, Reilly M P, FitzGerald G A

Abstract excerpt

Prostacyclin (PGI(2)), the major product of cyclooxygenase in macrovascular endothelium, mediates its biological effects through its cell surface G protein-coupled receptor, the IP. PKC-mediated phosphorylation of human (h) IP is a critical determinant of agonist-induced desensitization (Smyth, E. M., Hong Li, W., and FitzGerald, G. A. (1998) J. Biol. Chem. 273, 23258-23266). The regulatory events that follow...

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PMID: 10889200
DOI: 10.1074/jbc.M003873200

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