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Article

Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH).

American journal of medical genetics - 25 Jul 1997

Cubells J F, Kobayashi K, Nagatsu T, Kidd K K, Kidd J R, Calafell F, Kranzler H R, Ichinose H, Gelernter J

Abstract excerpt

Dopamine beta-hydroxylase (E.C. 1.14.17.1; protein abbreviation: DbetaH) catalyzes conversion of dopamine to norepinephrine. Previous work identified two expressed alleles of the gene encoding DbetaH (locus symbol DBH), containing either G or T at nucleotide position 910, resulting in specification by codon 304 of alanine (DBH*304A) or serine (DBH*304S), respectively. The current study employed denaturing...

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Source

Identifiers

PMID: 9259372
DOI: 10.1002/(sici)1096-8628(19970725)74:4<374::aid-ajmg7>3.0.co;2-p

Genes

DBH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Population genetics of a functional variant of the dopamine beta-hydroxylase gene (DBH).PMID 9259372Read ↗

A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.Semantic proximity Read ↗

Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C --> T) with plasma dopamine beta-hydroxylase activity.Semantic proximity Read ↗

Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans.Semantic proximity Read ↗

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Dopamine beta-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation.Semantic proximity Read ↗

Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology.Semantic proximity Read ↗

The catecholamine biosynthetic enzyme dopamine β-hydroxylase (DBH): first genome-wide search positions trait-determining variants acting additively in the proximal promoter.Semantic proximity Read ↗

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