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Article

DBH*444G/A polymorphism of the dopamine-beta-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2006

Köhnke M D, Kolb W, Köhnke A M, Lutz U, Schick S, Batra A

Abstract excerpt

As the enzyme dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine and both transmitters seem to be involved in the pathology of alcoholism and severe alcohol withdrawal symptoms, the gene encoding DbetaH (DBH) was applied to explore the genetic background of alcoholism and severe withdrawal symptoms. 102 healthy control subjects and 208 alcoholics, including 97 patients with a history of mild...

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Source

Identifiers

PMID: 16252068
DOI: 10.1007/s00702-005-0365-6

Genes

DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

DBH*444G/A polymorphism of the dopamine-beta-hydroxylase gene is associated with alcoholism but not with severe alcohol withdrawal symptoms.PMID 16252068Read ↗

A genotype-controlled analysis of plasma dopamine beta-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic function.Semantic proximity Read ↗

[Combination of DAT and DBH gene polymorphisms with a family history of alcohol use disorders increases the risk of withdrawal seizures and delirium tremens during alcohol withdrawal in alcohol-dependent men].Semantic proximity Read ↗

[The 444G/A and -1021 C/T polymorphisms of the dopamine-beta-hydroxylase gene modulate the trajectory of alcohol dependence development].Semantic proximity Read ↗

Association of functional DBH genetic variants with alcohol dependence risk and related depression and suicide attempt phenotypes: results from a large multicenter association study.Semantic proximity Read ↗

Association of the dopamine transporter gene with alcoholism.Semantic proximity Read ↗

Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction.Semantic proximity Read ↗

An exploratory study of candidate gene(s) for Delirium Tremens: Adding the new cholinergic dimension to the conundrum.Semantic proximity Read ↗

Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study.Semantic proximity Read ↗

Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence.Semantic proximity Read ↗

The polymorphism GABABR1 T1974C[rs29230] of the GABAB receptor gene is not associated with the diagnosis of alcoholism or alcohol withdrawal seizures.Semantic proximity Read ↗

The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure.Semantic proximity Read ↗

Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens.Semantic proximity Read ↗

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