Article
Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study.
Atherosclerosis - 1 Jan 2003
Jacques Paul F, Bostom Andrew G, Selhub Jacob, Rich Sharron, Ellison R Curtis, Eckfeldt John H, Gravel Roy A, Rozen Rima
Abstract excerpt
The metabolism of homocysteine requires contributions of several enzymes and vitamin cofactors. Earlier studies identified a common polymorphism of methylenetetrahydrofolate reductase that was associated with mild hyperhomocysteinemia. Common variants of two other enzymes involved in homocysteine metabolism, methionine synthase and methionine synthase reductase, have also been identified. Methionine synthase...
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