Article
Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese.
Atherosclerosis - 1 Oct 2002
Moriyama Yuri, Okamura Tomonori, Kajinami Kouji, Iso Hiroyasu, Inazu Akihiro, Kawashiri Masaaki, Mizuno Mihoko, Takeda Yoshiko, Sakamoto Yasuki, Kimura Humio, Suzuki Hideyoshi, Mabuchi Hiroshi
Abstract excerpt
High plasma homocysteine, a risk factor for atherosclerosis, is frequently caused by a common mutation in the gene for the enzyme, 5,10-methylenetetrahydrofolate reductase (MTHFR), C677T (alanine to valine substitution) or low intake of B vitamins that affect the remethylation or transsulfuration pathways in homocysteine metabolism. However, the interaction of the C677T mutation and B vitamins other than folate...
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