Article
The immediate-early 63 protein of Varicella-Zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo.
Journal of virology - 1 Feb 2004
Baiker Armin, Bagowski Christoph, Ito Hideki, Sommer Marvin, Zerboni Leigh, Fabel Klaus, Hay John, Ruyechan William, Arvin Ann M
Abstract excerpt
The immediate-early 63-kDa (IE63) protein of varicella-zoster virus (VZV) is a phosphoprotein encoded by open reading frame (ORF) ORF63/ORF70. To identify functional domains, 22 ORF63 mutations were evaluated for effects on IE63 binding to the major VZV transactivator, IE62, and on IE63 phosphorylation and nuclear localization in transient transfections, and after insertion into the viral genome with VZV cosmids....
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