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Article

Analysis of IE62 mutations found in Varicella-Zoster virus vaccine strains for transactivation activity.

Journal of microbiology (Seoul, Korea) - 1 Jun 2018

Ko Hyemin, Lee Gwang Myeong, Shin Ok Sarah, Song Moon Jung, Lee Chan Hee, Kim Young Eui, Ahn Jin-Hyun

Abstract excerpt

Live attenuated vaccine strains have been developed for Varicella-Zoster virus (VZV). Compared to clinically isolated strains, the vaccine strains contain several non-synonymous mutations in open reading frames (ORFs) 0, 6, 31, 39, 55, 62, and 64. In particular, ORF62, encoding an immediate-early (IE) 62 protein that acts as a transactivator for viral gene expression, contains six non-synonymous mutations, but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29858833
DOI: 10.1007/s12275-018-8144-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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