Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production.

Journal of virology - 1 Jan 2003

Bowles Dawn E, Rabinowitz Joseph E, Samulski R Jude

Abstract excerpt

Marker rescue, the restoration of gene function by replacement of a defective gene with a normal one by recombination, has been utilized to produce novel adeno-associated virus (AAV) vectors. AAV serotype 2 (AAV2) clones containing wild-type terminal repeats, an intact rep gene, and a mutated cap gene, served as the template for marker rescue. When transfected alone in 293 cells, these AAV2 mutant plasmids...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Capsid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chimera

Share to Dependovirus

Share to DNA, Viral

Share to HeLa Cells

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 12477847
DOI: 10.1128/jvi.77.1.423-432.2003
PMCID: PMC140636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production.PMID 12477847Read ↗

Identification and elimination of replication-competent adeno-associated virus (AAV) that can arise by nonhomologous recombination during AAV vector productionSemantic proximity Read ↗

AAV- based vector improvements unrelated to capsid protein modificationSemantic proximity Read ↗

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus VectorsSemantic proximity Read ↗

An Enhanced System for Construction of Adenoviral Vectors by the Two-Plasmid Rescue MethodSemantic proximity Read ↗

Evolving Membrane-Associated Accessory Protein Variants for Improved Adeno-associated Virus ProductionSemantic proximity Read ↗

Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production.Semantic proximity Read ↗

Improved Genome Packaging Efficiency of AAV Vectors Using Rep HybridsSemantic proximity Read ↗

High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and CapSemantic proximity Read ↗

Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV ReceptorSemantic proximity Read ↗

Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6Semantic proximity Read ↗

A High-Efficiency Cre/loxP-Based System for Construction of Adenoviral VectorsSemantic proximity Read ↗

CTCF regulates wild-type and recombinant AAV gene expression by shaping viral chromatinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.