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Article

Vps10p cycles between the TGN and the late endosome via the plasma membrane in clathrin mutants.

Molecular biology of the cell - 1 Dec 2002

Deloche Olivier, Schekman Randy W

Abstract excerpt

Clathrin-coated vesicles mediate the transport of the soluble vacuolar protein CPY from the TGN to the endosomal/prevacuolar compartment. Surprisingly, CPY sorting is not affected in clathrin deletion mutant cells. Here, we have investigated the clathrin-independent pathway that allows CPY transport to the vacuole. We find that CPY transport is mediated by the endosome and requires normal trafficking of its...

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Identifiers

PMID: 12475953
DOI: 10.1091/mbc.02-07-0105
PMCID: PMC138634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Vps10p cycles between the TGN and the late endosome via the plasma membrane in clathrin mutants.PMID 12475953Read ↗

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A family of small coiled-coil-forming proteins functioning at the late endosome in yeast.Semantic proximity Read ↗

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.Semantic proximity Read ↗

The yeast clathrin adaptor protein complex 1 is required for the efficient retention of a subset of late Golgi membrane proteins.Semantic proximity Read ↗

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles.Semantic proximity Read ↗

Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment.Semantic proximity Read ↗

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Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

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