Article
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.
The Journal of clinical investigation - 1 Apr 1997
Inoue I, Nakajima T, Williams C S, Quackenbush J, Puryear R, Powers M, Cheng T, Ludwig E H, Sharma A M, Hata A, Jeunemaitre X, Lalouel J M
Abstract excerpt
In earlier studies, we provided statistical evidence that individual differences in the angiotensinogen gene, the precursor of the vasoactive hormone angiotensin II, constitute inherited predispositions to essential hypertension in humans. We have now identified a common variant in the proximal promoter, the presence of an adenine, instead of a guanine, 6 bp upstream from the initiation site of transcription, in...
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