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Article

A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene.

Journal of cellular biochemistry - 1 Nov 2007

Konoshita Tadashi, Fuchs Sébastien, Makino Yasukazu, Wakahara Shigeyuki, Miyamori Isamu

Abstract excerpt

The regulation of renin gene expression is thought to be fundamental to regulation of the total renin-angiotensin system. The human renin gene contains a direct repeat (DR) motif AGGGGTCAC-AGGGCCA in the proximal region (-259/-245 bp), which contains similar sequence for nuclear receptor superfamily binding core motif, AGGTCA, and is the most similar to COUP-TFII consensus. The DR motif was evaluated as a...

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PMID: 17455195
DOI: 10.1002/jcb.21341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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