A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene.

doi:10.1002/jcb.21341

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene.

Journal of cellular biochemistry - 1 Nov 2007

Konoshita Tadashi, Fuchs Sébastien, Makino Yasukazu, Wakahara Shigeyuki, Miyamori Isamu

Abstract excerpt

The regulation of renin gene expression is thought to be fundamental to regulation of the total renin-angiotensin system. The human renin gene contains a direct repeat (DR) motif AGGGGTCAC-AGGGCCA in the proximal region (-259/-245 bp), which contains similar sequence for nuclear receptor superfamily binding core motif, AGGTCA, and is the most similar to COUP-TFII consensus. The DR motif was evaluated as a...

Topics

Amino Acid Motifs
Base Sequence
Binding Sites
COUP Transcription Factor II
Gene Expression Regulation
Humans
Mutation
Protein Binding
Receptors, Cytoplasmic and Nuclear
Regulatory Elements, Transcriptional
Renin
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 17455195
DOI: 10.1002/jcb.21341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics