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Article

Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family.

Journal of molecular biology - 3 Jan 2003

Seeliger M A, Breward S E, Itzhaki L S

Abstract excerpt

The human protein ckshs1 (cks1) is a 79 residue alpha/beta protein with low thermodynamic and kinetic stability. Its folding mechanism was probed by mutation at sites throughout the structure. Many of the mutations caused changes in the slope of the unfolding arm of the chevron plot. The effects can be rationalised in terms of either transition-state movement or native-state "breathing", and in either case, the...

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Identifiers

PMID: 12473461
DOI: 10.1016/s0022-2836(02)01202-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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