Article
HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais.
Tissue antigens - 1 Oct 2002
Stephens H A F, Klaythong R, Sirikong M, Vaughn D W, Green S, Kalayanarooj S, Endy T P, Libraty D H, Nisalak A, Innis B L, Rothman A L, Ennis F A, Chandanayingyong D
Abstract excerpt
Little is known of the role of classical HLA-A and -B class I alleles in determining resistance, susceptibility, or the severity of acute viral infections. Appropriate paradigms for immunogenetic studies of acute viral infections are dengue fever (DF) and dengue hemorrhagic fever (DHF). Both primary and secondary infections with dengue virus (DEN) serotypes 1, 2, 3 or 4, can result in either clinically less...
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