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Article

Beyond the rotamer library: genetic algorithm combined with the disturbing mutation process for upbuilding protein side-chains.

Proteins - 1 Jan 2003

Liu Zhijie, Jiang Lin, Gao Ying, Liang Shide, Chen Hao, Han Yuzhen, Lai Luhua

Abstract excerpt

The disturbing genetic algorithm, incorporating the disturbing mutation process into the genetic algorithm flow, has been developed to extend the searching space of side-chain conformations and to improve the quality of the rotamer library. Moreover, the growing generation amount idea, simulating the real situation of the natural evolution, is introduced to improve the searching speed. In the calculations using...

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PMID: 12471599
DOI: 10.1002/prot.10253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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