Article
Evolution models with base substitutions, insertions, deletions, and selection.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Dec 2008
Saakian D B
Abstract excerpt
The evolution model with parallel mutation-selection scheme is solved for the case when selection is accompanied by base substitutions, insertions, and deletions. The fitness is assumed to be either a single-peak function (i.e., having one finite discontinuity) or a smooth function of the Hamming distance from the reference sequence. The mean fitness is calculated exactly in large-genome limit. In the case of...
Topics
- Base Sequence
- Biophysical Phenomena
- Evolution, Molecular
- Models, Genetic
- Mutagenesis, Insertional
- Mutation
- Selection, Genetic
- Sequence Deletion