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Article

Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

4 Nov 2008

Abstract excerpt

We have generated mouse models of non-Hodgkin lymphoma (NHL) that rely on the cooperation between MYC overexpression and B-cell antigen receptor (BCR) signaling for the initiation and maintenance of B-cell lymphomas. Using these mouse models of NHL, we have focused on the identification of BCR-derived signal effectors that are important for the maintenance of NHL tumors. In the present study, we concentrate on...

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PMID: 18981293
DOI: 10.1182/blood-2008-05-158618

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