Article
Absence of both subunits of cytochrome b558 in the UM384 cell line relative to the inability to generate superoxide anions.
Experimental hematology - 1 Jul 1993
Champelovier P, Laporte F, Verhoeven A J, Hilarius P, de Klein A, Revol C, Seigneurin D, Kolodie L
Abstract excerpt
Phagocytic cells are characterized by their ability to generate superoxide anions upon activation by appropriate stimuli. UM384, a myelomonocytic cell line, was shown to be defective in this oxidase activity as measured by nitroblue tetrazolium or cytochrome c reduction. Cytochrome b558, a unique pigment present in phagocytes and implicated in electron transfer from NADPH to O2, was absent in the differentiated...
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