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Article

Isochores, GC3 and mutation biases in the human genome.

Gene - 30 Oct 2002

Alvarez-Valin Fernando, Lamolle Guillermo, Bernardi Giorgio

Abstract excerpt

In this work we re-examined the hypothesis that the variation in GC content in the human genome is due to different regional mutational biases. For this purpose we inferred the mutational pattern by using mutation databases that are available for many genes associated with human genetic diseases. The assumption of this approach is that such mutations reflect the actual frequency distribution of mutations as they...

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PMID: 12468097
DOI: 10.1016/s0378-1119(02)01043-0

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