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Article

Caged RNase: photoactivation of the enzyme from perfect off-state by site-specific incorporation of 2-nitrobenzyl moiety.

Bioorganic & medicinal chemistry letters - 6 Jan 2003

Hiraoka Takashi, Hamachi Itaru

Abstract excerpt

Photo-triggered activation of semisynthetic Ribonuclease S' from a perfect off-state was successfully carried out by incorporation of photo-labile caged moiety into a proximity to the active site.

Topics

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Amino Acid Sequence
Binding Sites
Mutagenesis, Site-Directed
Mutation
Peptide Fragments
Photolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12467607
DOI: 10.1016/s0960-894x(02)00825-9

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