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Article

Cat red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics.

The Journal of pharmacology and experimental therapeutics - 1 Feb 2004

Salavaggione Oreste E, Yang Chen, Kidd Linda B, Thomae Bianca A, Pankratz V Shane, Trepanier Lauren A, Weinshilboum Richard M

Abstract excerpt

A common genetic polymorphism for thiopurine S-methyltransferase (TPMT) is a major factor responsible for individual variation in the toxicity and therapeutic efficacy of thiopurine drugs in humans. We set out to determine whether inheritance might also influence the level of TPMT activity in the...

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Source

Identifiers

PMID: 14610243
DOI: 10.1124/jpet.103.059055

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14610243-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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