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Article

Characterization of a novel positive transcription regulatory element that differentially regulates the alpha-2-macroglobulin gene in replicative senescence.

Biogerontology - 1 Dec 2011

Li Renzhong, Ma Liwei, Huang Yu, Zhang Zongyu, Tong Tanjun

Abstract excerpt

Alpha-2-macroglobulin (α2M), a protease inhibitor, is implicated in Alzheimer's disease, atherosclerosis, and other age-related diseases. The elevated level of α2M mRNA has been described in replicative senescence and it could be used as a biomarker of the aging cells. However, the mechanism responsible for the up-regulation of its expression is still unclear. This report identified a novel transcriptional...

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PMID: 21541797
DOI: 10.1007/s10522-011-9339-2

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