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Article

Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Dec 2002

Clément K, Vega N, Laville M, Pelloux V, Guy-Grand B, Basdevant A, Vidal H

Abstract excerpt

BACKGROUND: In order to maintain body weight regulation, leptin directly or indirectly signals nutritional changes to key organs, but little is known about its target genes in human adipose tissue. Leptin receptor loss of function is a unique way to explore the role of leptin in the regulation of adipose tissue. OBJECTIVE: We studied the consequences of the absence of leptin signaling on adipocyte gene expression...

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Share to Adipocytes
Share to CCAAT-Enhancer-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Obesity, Morbid

Share to Receptors, Cell Surface

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Leptin

Share to Sequence Analysis, RNA

Share to Sterol Regulatory Element Binding Protein 1

Source

Identifiers

PMID: 12461669
DOI: 10.1038/sj.ijo.0802180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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