Article
Assay of cytomegalovirus susceptibility to ganciclovir in renal and heart transplant recipients.
Transplant international : official journal of the European Society for Organ Transplantation - 1 Nov 2002
de Oña Navarro María, Melón Santiago, Méndez Susana, Iglesias Beatriz, Palacio Ana, Bernardo María J, Rodriguez-Lambert José L, Gómez Ernesto
Abstract excerpt
Ganciclovir (GCV) prophylaxis or pre-emptive therapy significantly reduce the rate of cytomegalovirus (CMV) disease and viremia, but increase the potential for emergence of ganciclovir-resistant CMV strains. The inhibitor concentration at 50% (IC(50)) of GCV from 156 CMV isolates from 59 renal or heart transplant recipients was calculated by means of a rapid phenotypic susceptibility assay. Twenty-seven strains...
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