Article
Rapid detection and quantitation of ganciclovir resistance in cytomegalovirus quasispecies.
Journal of medical virology - 1 Jul 2013
Ruiz-Carrascoso Guillermo, Romero-Gómez María Pilar, Plaza Diego, Mingorance Jesús
Abstract excerpt
Human cytomegalovirus (HCMV) may cause severe or fatal disease among immunocompromised patients. The first line prophylaxis and systemic HCMV disease therapy is ganciclovir (GCV). The presence of GCV-resistant virus has been linked to fatal HCMV disease. The implementation of rapid and sensitive techniques for the early detection and monitoring of GCV-resistance may be helpful to support antiviral therapy...
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